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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10131637 B1

PDFFull Text
Date of Patent:
Nov. 20, 2018

Filed:

Mar. 11, 2014

Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases

Applicants:

Shifa Biomedical Corporation, Malvern, PA (US);

Temple University—of the Commonwealth System of Higher Education, Philadelphia, PA (US);

Inventors:

Sherin Salaheldin Abdel-Meguid, Exton, PA (US);

Magid Abou-Gharbia, Exton, PA (US);

Benjamin Blass, Eagleville, PA (US);

Wayne Childers, New Hope, PA (US);

Nabil Elshourbagy, West Chester, PA (US);

Victor Ghidu, Philadelphia, PA (US);

Rogelio Martinez, Trenton, NJ (US);

Harold Meyers, Weston, MA (US);

Shaker A. Mousa, Wynantskill, NY (US);

Assignees:

Shifa Biomedical Corporation, Malvern, PA (US);

Temple University—Of The Commonwealth System of Higher Education, Philadelphia, PA (US);

Attorneys:

Robert C. Netter, Jr.

Dann, Dorfman, Herrell and Skillman, P.C.

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A61K 31/4965 (2006.01); C07D 239/42 (2006.01); C07C 271/28 (2006.01); C07C 275/42 (2006.01); C07C 311/47 (2006.01); C07C 235/38 (2006.01); C07C 237/42 (2006.01); C07D 403/12 (2006.01); C07D 213/74 (2006.01); C07D 213/82 (2006.01); C07D 231/12 (2006.01); C07D 233/90 (2006.01); C07D 401/06 (2006.01); C07D 241/04 (2006.01); C07D 241/08 (2006.01); C07D 471/04 (2006.01); C07D 261/08 (2006.01); C07D 295/14 (2006.01); C07D 211/70 (2006.01); A61K 31/167 (2006.01); A61K 31/17 (2006.01); A61K 31/18 (2006.01); A61K 31/235 (2006.01); A61K 31/397 (2006.01); A61K 31/401 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/42 (2006.01); A61K 31/435 (2006.01); A61K 31/437 (2006.01); A61K 31/4418 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/245 (2006.01); A61K 31/40 (2006.01); C07C 275/40 (2006.01); C07D 211/14 (2006.01); C07D 211/96 (2006.01); C07D 213/68 (2006.01);
U.S. Cl.
CPC ...
C07D 239/42 (2013.01); A61K 31/167 (2013.01); A61K 31/17 (2013.01); A61K 31/18 (2013.01); A61K 31/235 (2013.01); A61K 31/245 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/401 (2013.01); A61K 31/415 (2013.01); A61K 31/4164 (2013.01); A61K 31/42 (2013.01); A61K 31/435 (2013.01); A61K 31/437 (2013.01); A61K 31/4418 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); C07C 235/38 (2013.01); C07C 237/42 (2013.01); C07C 271/28 (2013.01); C07C 275/40 (2013.01); C07C 275/42 (2013.01); C07C 311/47 (2013.01); C07D 211/14 (2013.01); C07D 211/70 (2013.01); C07D 211/96 (2013.01); C07D 213/68 (2013.01); C07D 213/74 (2013.01); C07D 213/82 (2013.01); C07D 231/12 (2013.01); C07D 233/90 (2013.01); C07D 241/04 (2013.01); C07D 241/08 (2013.01); C07D 261/08 (2013.01); C07D 295/14 (2013.01); C07D 401/06 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01); C07C 2601/02 (2017.05); C07C 2601/08 (2017.05);
Abstract

Disclosed are compounds of the class of 2-phenylacetamides that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), and methods of using these modulators to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia.

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