The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2018
Filed:
May. 13, 2015
Snu R&db Foundation, Seoul, KR;
Postech Academy-industry Foundation, Gyeongsangbuk-do, KR;
Dong Soo Lee, Seoul, KR;
Do Won Hwang, Seoul, KR;
Hongyoon Choi, Seoul, KR;
Yun-Sang Lee, Seoul, KR;
Jae Min Jeong, Seoul, KR;
Yong Song Gho, Gyeongsangbuk-do, KR;
Su Chul Jang, Gyeongsangbuk-do, KR;
SNU R&DB FOUNDATION, Seoul, KR;
POSTECH ACADEMY—INDUSTRY FOUNDATION, Gyeongsangbuk-Do, KR;
Abstract
A method for labeling exosomes with a radioactive substance using an amine group on surfaces of the exosomes includes providing a cell-derived exosome, treating a surface of the exosome with N-hydroxysuccinimide-azadibenzocyclooctyne (NHS-ADIBO), and mixing the treated exosome with N3-introduced chelator-radioactive substance to conduct a reaction between the chelator and an amine group present on the surface of the exosome, wherein the radioactive substance is introduced inside the exosome by the above reaction. The exosomes can be stably labeled at high labeling efficiency, and the exosomes can be favorably used as an agent for nuclear medicine imaging and therapeutic imaging for confirming the biological distribution of exosomes and whether the exosomes move to target organs and target diseases in animals including a human being.