The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2018
Filed:
Mar. 26, 2012
Michael John Zaworotko, Tampa, FL (US);
Roland D. Shytle, Largo, FL (US);
Tien Teng Ong, Singapore, SG;
Ryan N. Cantwell, Melbourne, FL (US);
Tranhha Nguyen, Tampa, FL (US);
Adam John Smith, Tampa, FL (US);
Padmini Kavuru, West Lafayette, IN (US);
Michael John Zaworotko, Tampa, FL (US);
Roland D. Shytle, Largo, FL (US);
Tien Teng Ong, Singapore, SG;
Ryan N. Cantwell, Melbourne, FL (US);
Tranhha Nguyen, Tampa, FL (US);
Adam John Smith, Tampa, FL (US);
Padmini Kavuru, West Lafayette, IN (US);
University of South Florida, Tampa, FL (US);
Abstract
2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (LiZMOM) and several lithium diamondoid metal-organic materials (LiDMOMs). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the CNS. Advantageously, the novel cocrystal forms described herein may be used to lower the oral dose required to achieve therapeutic concentrations of lithium in the brain, thus reducing the peripheral toxicity and potentially broadening the therapeutic index in comparison to conventional lithium forms.