The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2018
Filed:
Jul. 23, 2015
Applicant:
The Pirbright Institute, Pirbright, Woking, GB;
Inventors:
Assignee:
THE PIRBRIGHT INSTITUTE, Woking, Pirbright, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/215 (2006.01); C12N 7/00 (2006.01); C12N 9/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/215 (2013.01); C12N 7/00 (2013.01); C12N 9/127 (2013.01); C12Y 207/07048 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/54 (2013.01); C12N 2770/20021 (2013.01); C12N 2770/20022 (2013.01); C12N 2770/20034 (2013.01); C12N 2770/20051 (2013.01); C12N 2770/20062 (2013.01);
Abstract
The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.