The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 13, 2018

Filed:

Nov. 29, 2017
Applicant:

Pfizer Inc., New York, NY (US);

Inventors:

Aaron Craig Burns, San Diego, CA (US);

Michael Raymond Collins, San Diego, CA (US);

Samantha Elizabeth Greasley, San Diego, CA (US);

Robert Louis Hoffman, Carlsbad, CA (US);

Peter Qinhua Huang, San Diego, CA (US);

Robert Steven Kania, Solana Beach, CA (US);

Pei-Pei Kung, San Diego, CA (US);

Maria Angelica Linton, San Diego, CA (US);

Lakshmi Sourirajan Narasimhan, San Diego, CA (US);

Paul Francis Richardson, San Diego, CA (US);

Daniel Tyler Richter, San Diego, CA (US);

Graham Smith, San Diego, CA (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 417/08 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); C07D 277/46 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); C07D 417/08 (2013.01); A61K 31/427 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 277/46 (2013.01); C07D 401/14 (2013.01);
Abstract

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R-R, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.


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