The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2018
Filed:
Dec. 16, 2014
Brandeis University, Waltham, MA (US);
University of Georgia Research Foundation, Inc., Athens, GA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Lizbeth K. Hedstrom, Newton, MA (US);
Gregory D. Cuny, Houston, TX (US);
Deviprasad R. Gollapalli, Waltham, MA (US);
Sivapriya Kirubakaran, Chennai, IN;
Sushil K. Maurya, Leeds, GB;
Boris Striepen, Athens, GA (US);
Suresh K. Gorla, Gurgaon, IN;
Corey R. Johnson, Waltham, MA (US);
Mandapati Kavitha, Gurgaon, IN;
Jihan Khan, Somerville, MA (US);
Brandeis University, Waltham, MA (US);
University of Georgia Research Foundation, Inc., Athens, GA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.