The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2018
Filed:
Jun. 08, 2016
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Kimberly Kelly, Crozet, VA (US);
Ralph Weissleder, Peabody, MA (US);
Nabeel Bardeesy, Framingham, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 49/14 (2006.01); A61K 49/00 (2006.01); A61K 49/18 (2006.01); B82Y 5/00 (2011.01); C07K 7/06 (2006.01); G01N 33/531 (2006.01); G01N 33/533 (2006.01); G01N 33/574 (2006.01); C07K 16/18 (2006.01); A61K 38/08 (2006.01); G01N 33/543 (2006.01); A61K 47/64 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 49/14 (2013.01); A61K 38/08 (2013.01); A61K 47/64 (2017.08); A61K 49/0002 (2013.01); A61K 49/0032 (2013.01); A61K 49/0056 (2013.01); A61K 49/1818 (2013.01); B82Y 5/00 (2013.01); C07K 7/06 (2013.01); C07K 16/18 (2013.01); G01N 33/531 (2013.01); G01N 33/533 (2013.01); G01N 33/54326 (2013.01); G01N 33/54346 (2013.01); G01N 33/57438 (2013.01); A61K 38/00 (2013.01);
Abstract
Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying 'accessible' proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.