The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2018
Filed:
Apr. 21, 2016
Applicant:
Kansas State University Research Foundation, Manhattan, KS (US);
Inventors:
Deryl Troyer, Manhattan, KS (US);
Duane Davis, Westmoreland, KS (US);
Stefan Bossmann, Manhattan, KS (US);
Assignee:
Kansas State University Research Foundation, Manhattan, KS (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/00 (2006.01); C12N 5/02 (2006.01); C12N 15/00 (2006.01); A01K 67/027 (2006.01); A61K 49/00 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A01K 67/0271 (2013.01); A61K 49/0008 (2013.01); A01K 2207/12 (2013.01); A01K 2207/15 (2013.01); A01K 2227/105 (2013.01); A01K 2227/108 (2013.01); A01K 2267/0331 (2013.01); A61K 35/12 (2013.01); A61K 2035/122 (2013.01);
Abstract
Immunocompetent animal models having immunological tolerance to a xenograft and methods of producing the same. The animal models are tolerized to the xenograft in the pre-immune, fetal or embryonic stage, followed by transplanting the xenograft into the animal in the post-natal stage, such that the post-natal animal is immunologically tolerant to the xenograft, while remaining immunocompetent.