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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10119202 B1

PDFFull Text
Date of Patent:
Nov. 06, 2018

Filed:

Apr. 30, 2013

Method for preparing electro-mechanically stretched hydrogel micro fibers

Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Hai-Quan Mao, Baltimore, MD (US);

Shuming Zhang, Lehigh Acres, FL (US);

Xi Liu, Suzhou, CN;

Brian Patrick Ginn, Baltimore, MD (US);

Assignee:

THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);

Attorneys:

Casimir Jones, S.C.

Jeffrey W. Childers

Primary Examiner:

Leo B Tentoni

Int. Cl.
CPC ...
D01D 5/34 (2006.01); D01D 7/00 (2006.01); D01D 10/02 (2006.01); D01F 1/10 (2006.01); D01F 4/00 (2006.01); D01F 6/14 (2006.01); D01F 6/16 (2006.01); D01F 6/50 (2006.01); D01F 6/52 (2006.01); D01F 6/60 (2006.01); D01F 6/62 (2006.01); D01F 8/02 (2006.01); D01F 8/10 (2006.01); D01F 8/12 (2006.01); D01F 8/14 (2006.01); D01F 11/02 (2006.01); D01F 11/06 (2006.01); D01D 5/00 (2006.01); D06M 10/00 (2006.01); D01D 5/06 (2006.01); D01D 5/12 (2006.01); A61L 27/48 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); D01F 2/00 (2006.01);
U.S. Cl.
CPC ...
D01D 5/003 (2013.01); A61L 27/48 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); D01D 5/0046 (2013.01); D01D 5/0076 (2013.01); D01D 5/06 (2013.01); D01D 5/12 (2013.01); D01F 2/00 (2013.01); D06M 10/001 (2013.01); A61L 2430/00 (2013.01); D10B 2201/01 (2013.01); D10B 2211/01 (2013.01); Y10T 428/298 (2015.01); Y10T 428/2967 (2015.01);
Abstract

The presently disclosed subject matter provides a scalable and electrostretching approach for generating microfibers exhibiting uniaxial alignment from polymer solutions. Such microfibers can be generated from a variety of natural polymers or synthetic polymers. The hydrogel microfibers can be used for controlled release of bioactive agents. The internal uniaxial alignment exhibited by the presently disclosed fibers provides improved mechanical properties to microfibers, contact guidance cues and induces alignment for cells seeded on or within the microfibers.

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