The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2018
Filed:
Jul. 05, 2017
Applicants:
Baylor College of Medicine, Houston, TX (US);
Texas Heart Institute, Houston, TX (US);
Inventors:
James F. Martin, Pearland, TX (US);
Yuka Morikawa, Houston, TX (US);
Todd Ryan Heallen, Houston, TX (US);
John Leach, Houston, TX (US);
Assignees:
Baylor College of Medicine, Houston, TX (US);
Texas Heart Institute, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/11 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01); A61K 31/713 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/30 (2013.01); C12N 2740/15043 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.