The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2018
Filed:
Jun. 26, 2017
Applicants:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Schepens Eye Research Institute, Boston, MA (US);
Inventors:
Luk H. Vandenberghe, Weston, MA (US);
Eric Zinn, Cambridge, MA (US);
Assignees:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Schepens Eye Research Institute, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/23 (2006.01); A61K 39/00 (2006.01); C12N 7/00 (2006.01); C07K 14/00 (2006.01); C12N 15/86 (2006.01); C07K 14/005 (2006.01); C07K 16/22 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 39/00 (2013.01); C07K 14/00 (2013.01); C07K 14/005 (2013.01); C07K 16/22 (2013.01); C12N 15/86 (2013.01); A61K 2039/525 (2013.01); A61K 2039/6075 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14123 (2013.01); C12N 2750/14141 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01);
Abstract
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.