The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2018
Filed:
Oct. 03, 2014
Xencor, Inc., Monrovia, CA (US);
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Gregory Alan Lazar, Los Angeles, CA (US);
Bassil I. Dahiyat, Altadena, CA (US);
Hisafumi Okabe, Kanagawa, JP;
Masamichi Sugimoto, Kanagawa, JP;
Shigeyuki Iijima, Shizuoka, JP;
Izumi Sugo, Shizuoka, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Xencor, Inc., Monrovia, CA (US);
Abstract
An anti-glypican-3 antibody comprising one or more amino acid substitutions introduced in the Fc region is disclosed. Preferably, in the anti-glypican-3 antibody, one or more of the amino acid residues at the positions 239, 298, 326, 330 and 332 in the Fc region are substituted with other amino acid residues. Since the Fc-modified anti-glypican-3 antibody of the invention exhibit enhanced ADCC activity, it is useful in treating cancers, such as hepatic cancer. Also disclosed are an anticancer agent comprising the anti-glypican-3 antibody of the invention and a pharmaceutically acceptable carrier, as well as a method of treating a patient with cancer comprising administering to the patient the anticancer agent of the invention.