The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2018
Filed:
Mar. 25, 2016
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
The Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);
University of South Florida, Tampa, FL (US);
David L. Morse, Tampa, FL (US);
Josef Vagner, Tucson, AZ (US);
Mark McLaughlin, Tampa, FL (US);
Robert Gillies, Tampa, FL (US);
Amanda Huynh, Land O Lakes, FL (US);
Michael Doligalski, Lutz, FL (US);
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
The Arizona Board of Regents on behalf of the University of Arizona, Tucson, AZ (US);
University of South Florida, Tampa, FL (US);
Abstract
Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.