The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 06, 2018

Filed:

May. 15, 2017
Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Edward Roberts, Fallbrook, CA (US);

Miguel A. Guerrero, San Diego, CA (US);

Mariangela Urbano, Del Mar, CA (US);

Hugh Rosen, La Jolla, CA (US);

Assignee:

The Scripps Research Institute, La Jolla, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 25/04 (2006.01); A61K 31/4545 (2006.01); A61P 37/02 (2006.01); A61K 31/435 (2006.01); A61P 25/28 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/04 (2006.01); C07D 211/58 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); C07D 211/58 (2013.01); C07D 401/04 (2013.01); C07D 413/14 (2013.01);
Abstract

The invention provides novel ligands of Kappa (κ) opioid receptors, such as can be used to modulate a Kappa opioid receptor. Methods of synthesis and methods of use are also provided. Compounds of the invention can be used therapeutically in the treatment of dissociative disorders or pain, or to provide neuroprotection, or to induce diuresis, or to modulate the immune system, or for treatment of one or more of an affective disorders comprising depression or stress/anxiety; an addictive disorder; alcoholism, epilepsy; a cognition deficiency; schizophrenia; Alzheimer's disease; or pain.


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