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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10118895 B1

PDFFull Text
Date of Patent:
Nov. 06, 2018

Filed:

Jun. 03, 2016

Ror gamma (rorγ) modulators

Applicants:

Lead Pharma Holding B.v., Nijmegen, NL;

Sanofi, Paris, FR;

Inventors:

Joseph Maria Gerardus Barbara Cals, Oss, NL;

David Machnik, Paris, FR;

Sander Bernardus Nabuurs, Oss, NL;

Jean-Francois Sabuco, Paris, FR;

Laurent Schio, Paris, FR;

Assignees:

LEAD PHARMA HOLDING B.V., Nijmegen, NL;

SANOFI, Paris, FR;

Attorney:

Oliff PLC

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
C07D 213/71 (2006.01); C07D 237/18 (2006.01); C07D 239/38 (2006.01); C07D 405/12 (2006.01); A61K 31/44 (2006.01); A61K 31/4965 (2006.01); A61K 31/50 (2006.01); A61K 31/444 (2006.01); A61K 31/4427 (2006.01); A61K 31/505 (2006.01); C07D 241/18 (2006.01);
U.S. Cl.
CPC ...
C07D 213/71 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4427 (2013.01); A61K 31/4965 (2013.01); A61K 31/50 (2013.01); A61K 31/505 (2013.01); C07D 237/18 (2013.01); C07D 239/38 (2013.01); C07D 241/18 (2013.01); C07D 405/12 (2013.01);
Abstract

Novel compounds according to Formula I Meta or para or a pharmaceutically acceptable salt thereof wherein:A-Aare N or CR, CR, CR, CR, respectively, with the proviso that no more than two of the four positions A in A-Acan be simultaneously N; A, A, A, A, Aare N or CR, CR, CR, CR, CR, respectively, with the proviso that at least one but no more than two of the five positions A in A, A, A, A, Ais N; Ris C(2-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, (di)C(3-6)cycloalkylamino or (di)(C(3-6)cycloalkylC(1-3)alkyl)amino; Ris H, hydroxyethyl, methoxyethyl, C(1-6)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl; the sulfonyl group with Ris represented by one of R, Ror R; Ris H, C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkyl-C(1-3)alkyl; and Ris C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkyl-C(1-3)alkyl.

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