The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 06, 2018

Filed:

Apr. 14, 2017
Applicant:

Esperion Therapeutics, Inc., Ann Arbor, MI (US);

Inventors:

Jean-Louis H. Dasseux, Toulouse, FR;

Carmen D. Oniciu, Toulouse, FR;

Assignee:

Esperion Therapeutics, Inc., Ann Arbor, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/20 (2006.01); C07C 31/27 (2006.01); C07C 61/12 (2006.01); C07C 47/34 (2006.01); C07C 309/25 (2006.01); C07F 9/24 (2006.01); C07D 261/12 (2006.01); C07C 59/105 (2006.01); C07C 33/26 (2006.01); C07C 47/19 (2006.01); C07C 69/675 (2006.01); C07C 69/003 (2006.01); C07C 69/017 (2006.01); C07C 309/08 (2006.01); C07C 309/24 (2006.01); C07F 9/12 (2006.01); C07D 261/08 (2006.01); C07C 59/01 (2006.01); A61K 31/194 (2006.01); A61K 31/23 (2006.01); A61K 31/191 (2006.01); C07C 31/20 (2006.01); C07C 31/22 (2006.01); C07C 31/24 (2006.01); C07C 59/11 (2006.01); C07C 59/245 (2006.01); C07C 59/285 (2006.01); C07C 59/29 (2006.01); C07C 59/46 (2006.01); C07C 59/48 (2006.01); C07C 59/54 (2006.01); C07C 62/02 (2006.01); C07C 62/06 (2006.01); C07C 65/17 (2006.01); C07C 69/757 (2006.01); C07D 213/80 (2006.01); C07D 309/10 (2006.01); C07D 309/12 (2006.01); C07D 405/12 (2006.01); C07F 9/09 (2006.01); C07F 9/117 (2006.01); C07F 9/44 (2006.01);
U.S. Cl.
CPC ...
C07C 31/27 (2013.01); A61K 31/191 (2013.01); A61K 31/194 (2013.01); A61K 31/20 (2013.01); A61K 31/23 (2013.01); C07C 31/20 (2013.01); C07C 31/22 (2013.01); C07C 31/24 (2013.01); C07C 33/26 (2013.01); C07C 47/19 (2013.01); C07C 47/34 (2013.01); C07C 59/01 (2013.01); C07C 59/105 (2013.01); C07C 59/11 (2013.01); C07C 59/245 (2013.01); C07C 59/285 (2013.01); C07C 59/29 (2013.01); C07C 59/46 (2013.01); C07C 59/48 (2013.01); C07C 59/54 (2013.01); C07C 61/12 (2013.01); C07C 62/02 (2013.01); C07C 62/06 (2013.01); C07C 65/17 (2013.01); C07C 69/003 (2013.01); C07C 69/017 (2013.01); C07C 69/675 (2013.01); C07C 69/757 (2013.01); C07C 309/08 (2013.01); C07C 309/24 (2013.01); C07C 309/25 (2013.01); C07D 213/80 (2013.01); C07D 261/08 (2013.01); C07D 261/12 (2013.01); C07D 309/10 (2013.01); C07D 309/12 (2013.01); C07D 405/12 (2013.01); C07F 9/093 (2013.01); C07F 9/094 (2013.01); C07F 9/117 (2013.01); C07F 9/12 (2013.01); C07F 9/242 (2013.01); C07F 9/2408 (2013.01); C07F 9/2416 (2013.01); C07F 9/2425 (2013.01); C07F 9/4423 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05);
Abstract

The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.


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