The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2018
Filed:
Jul. 09, 2014
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Baylor College of Medicine, Houston, TX (US);
Anu Puri, Frederick, MD (US);
Robert P. Blumenthal, Bethesda, MD (US);
Amit Joshi, Houston, TX (US);
Darayash B. Tata, Silver Spring, MD (US);
Mathias Viard, Frederick, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Baylor College of Medicine, Houston, TX (US);
Abstract
Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DCPC), dipalmitoylphosphatidylcholine (DPPC), and (ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an agent within the cavity.