The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2018
Filed:
Oct. 16, 2017
Applicant:
Ono Pharmaceutical Co., Ltd., Osaka, JP;
Inventors:
Atsushi Naganawa, Osaka, JP;
Kensuke Kusumi, Osaka, JP;
Kazuhiro Otsuki, Osaka, JP;
Tetsuya Sekiguchi, Osaka, JP;
Akito Kakuuchi, Osaka, JP;
Koji Shinozaki, Osaka, JP;
Hiroshi Yamamoto, Osaka, JP;
Shigeyuki Nonaka, Osaka, JP;
Assignee:
ONO PHARMACEUTICAL CO., LTD., Osaka, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); C07D 405/12 (2006.01); C07D 205/04 (2006.01); C07D 211/48 (2006.01); C07D 207/16 (2006.01); C07D 211/52 (2006.01); C07D 207/12 (2006.01); C07D 401/12 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/4523 (2006.01); A61K 31/453 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01);
U.S. Cl.
CPC ...
A61K 31/445 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/453 (2013.01); A61K 31/454 (2013.01); A61K 31/4523 (2013.01); A61K 31/4545 (2013.01); C07D 205/04 (2013.01); C07D 207/12 (2013.01); C07D 207/16 (2013.01); C07D 211/48 (2013.01); C07D 211/52 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01);
Abstract
The compound of the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1Pantagonistic activity. The compound may therefore be used as a therapeutic agent for S1P-mediated diseases such as diseases resulting from vascular constriction, fibrosis, and respiratory diseases.