IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10117858 B1

PDFFull Text
Date of Patent:
Nov. 06, 2018

Filed:

May. 17, 2016

Pyridine and pyrazine derivative for the treatment of cf

Applicant:

Novartis Ag, Basel OT, CH;

Inventors:

Urs Baettig, Horsham, GB;

Kamlesh Bala, Horsham, GB;

Emma Budd, Horsham, GB;

Lee Edwards, Partridge Green, GB;

Catherine Howsham, Horsham, GB;

Glyn Alan Hughes, Horsham, GB;

Darren Mark LeGrand, East Grinstead, GB;

Katrin Spiegel, Horsham, GB;

Assignee:

Novartis AG, Basel, CH;

Attorney:

Wendy F. Ballard

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 31/443 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4412 (2006.01); A61K 31/4545 (2006.01); A61K 31/4965 (2006.01); A61K 31/497 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); A61K 31/4418 (2006.01); C07D 213/81 (2006.01); C07D 241/28 (2006.01); C07D 401/04 (2006.01); C07D 405/12 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 213/38 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/04 (2006.01); C07D 241/26 (2006.01);
U.S. Cl.
CPC ...
A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/444 (2013.01); A61K 31/4412 (2013.01); A61K 31/4418 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/497 (2013.01); A61K 31/4965 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 213/38 (2013.01); C07D 213/81 (2013.01); C07D 241/26 (2013.01); C07D 241/28 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01);
Abstract

The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

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