The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 30, 2018

Filed:

Mar. 04, 2016
Applicant:

Purdue Research Foundation, West Lafayette, IN (US);

Inventors:

Garth Jason Simpson, West Lafayette, IN (US);

Justin Allen Newman, West Lafayette, IN (US);

Nicholas Roman Pogranichniy, West Lafayette, IN (US);

Nicole Mulready Scarborough, West Lafayette, IN (US);

Assignee:

Purdue Research Foundation, West Lafayette, IN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G02F 1/37 (2006.01); G01N 21/63 (2006.01); G01N 33/52 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01); G01N 23/207 (2018.01);
U.S. Cl.
CPC ...
G01N 21/636 (2013.01); G01N 23/207 (2013.01); G01N 33/52 (2013.01); G01N 33/58 (2013.01); G01N 33/68 (2013.01); G02F 1/37 (2013.01);
Abstract

Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.


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