The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2018
Filed:
Mar. 31, 2016
Applicant:
Novimmune SA, Geneva, CH;
Inventors:
Giovanni Magistrelli, Cessy, FR;
Pauline Malinge, Cernex, FR;
Yves Poitevin, Ambilly, FR;
Nicolas Fischer, Geneva, CH;
Assignee:
NovImmune SA, Geneva, CH;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 16/18 (2006.01); C07K 16/46 (2006.01); C12P 21/02 (2006.01); C12N 15/85 (2006.01); C12N 15/67 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 16/18 (2013.01); C07K 16/468 (2013.01); C12N 15/67 (2013.01); C12N 15/85 (2013.01); C12P 21/02 (2013.01); C07K 2317/31 (2013.01);
Abstract
Methods are provided to improve the expression of protein complexes by tuning the expression levels of each component required for the assembly of the complex. These methods are effective in limiting the expression of the dominant chain and, thus, equilibrating their relative abundance. The methods provided herein lead to a significant increase in productivity and final bispecific yields both in transient expression systems as well as in stably transfected mammalian cells.