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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10113193 B1

PDFFull Text
Date of Patent:
Oct. 30, 2018

Filed:

Mar. 31, 2016

Method for optimizing the assembly and production of hetero-multimeric protein complexes

Applicant:

Novimmune SA, Geneva, CH;

Inventors:

Giovanni Magistrelli, Cessy, FR;

Pauline Malinge, Cernex, FR;

Yves Poitevin, Ambilly, FR;

Nicolas Fischer, Geneva, CH;

Assignee:

NovImmune SA, Geneva, CH;

Attorneys:

Cooley LLP

Ivor R. Elrifi

Cynthia Kozakiewicz

Primary Examiner:

Suzanne M Noakes

Assistant Examiner:

Jae W Lee

Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 16/18 (2006.01); C07K 16/46 (2006.01); C12P 21/02 (2006.01); C12N 15/85 (2006.01); C12N 15/67 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 16/18 (2013.01); C07K 16/468 (2013.01); C12N 15/67 (2013.01); C12N 15/85 (2013.01); C12P 21/02 (2013.01); C07K 2317/31 (2013.01);
Abstract

Methods are provided to improve the expression of protein complexes by tuning the expression levels of each component required for the assembly of the complex. These methods are effective in limiting the expression of the dominant chain and, thus, equilibrating their relative abundance. The methods provided herein lead to a significant increase in productivity and final bispecific yields both in transient expression systems as well as in stably transfected mammalian cells.

Find Patent Forward Citations

Magistrelli, Giovanni. (2018). Method for optimizing the assembly and production of hetero-multimeric protein complexes (U.S. Patent No. 10113193). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10113193

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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