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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10112980 B1

PDFFull Text
Date of Patent:
Oct. 30, 2018

Filed:

May. 18, 2017

Mutated immunoglobulin-binding polypeptides

Applicant:

GE Healthcare Bioprocess R&d Ab, Uppsala, SE;

Inventors:

Mats Ander, Uppsala, SE;

Goran Bauren, Uppsala, SE;

Tomas Bjorkman, Uppsala, SE;

Gustav Rodrigo, Uppsala, SE;

Assignee:

GE HEALTHCARE BIOPROCESS R&D AB, Uppsala, SE;

Attorney:

Wood IP LLC

Primary Examiner:

Maury A Audet

Int. Cl.
CPC ...
C07K 14/31 (2006.01); C07K 14/745 (2006.01); C07K 16/00 (2006.01); C07K 1/22 (2006.01); B01D 15/38 (2006.01); B01J 20/32 (2006.01); B01J 20/286 (2006.01);
U.S. Cl.
CPC ...
C07K 14/31 (2013.01); B01D 15/3809 (2013.01); B01J 20/286 (2013.01); B01J 20/3204 (2013.01); B01J 20/3212 (2013.01); B01J 20/3219 (2013.01); B01J 20/3274 (2013.01); C07K 1/22 (2013.01); C07K 14/745 (2013.01); C07K 16/00 (2013.01);
Abstract

The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamic acid residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.

Find Patent Forward Citations

Ander, Mats. (2018). Mutated immunoglobulin-binding polypeptides (U.S. Patent No. 10112980). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10112980

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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