The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2018
Filed:
Aug. 24, 2015
Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v., Munich, DE;
Universitat Zu Koln, Cologne, DE;
Bernd Neumaier, Hurth, DE;
Boris Zlatopolskiy, Cologne, DE;
Raphael Richarz, Leverkusen, DE;
Phillip Krapf, Much, DE;
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Munich, DE;
Universitat Zu Koln, Cologne, DE;
Abstract
Novel efficient, time-saving and reliable radiofluorination procedures for the production ofF-labelled active esters via nucleophilic substitution of the corresponding onium precursors withFare described. The active ester including [F]F-Py-TFP and [F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor.