The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2018
Filed:
Jun. 15, 2015
Applicant:
Peptimed, Inc., Madison, WI (US);
Inventors:
Thomas Primiano, Monona, WI (US);
Bey-Dih Chang, Madison, WI (US);
Assignee:
PeptiMed, Inc., Madison, WI (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); A61K 31/713 (2006.01); C12N 15/117 (2010.01); A61K 9/127 (2006.01); A61K 45/06 (2006.01); A61K 47/64 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 9/127 (2013.01); A61K 9/1271 (2013.01); A61K 45/06 (2013.01); A61K 47/646 (2017.08); A61K 47/6935 (2017.08); C12N 15/117 (2013.01); C12N 2310/17 (2013.01); C12N 2310/351 (2013.01);
Abstract
Disclosed herein are oligonucleotide sequences that generate innate immunity in cells within tumors upon its delivery into tumors. In certain embodiments, these oligonucleotides are specifically delivered into tumors through nanoparticles displaying targeting peptides that confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.