The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Aug. 23, 2017
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Igor Slukvin, Verona, WI (US);
Irina Elcheva, Madison, WI (US);
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/0735 (2010.01); C12N 15/00 (2006.01); C12N 5/0789 (2010.01); C12N 15/66 (2006.01); C12N 5/071 (2010.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0606 (2013.01); C12N 5/0608 (2013.01); C12N 5/0647 (2013.01); C12N 15/00 (2013.01); C12N 15/66 (2013.01); C12N 15/11 (2013.01); C12N 2501/60 (2013.01); C12N 2501/998 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01); C12N 2740/16043 (2013.01);
Abstract
Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.