The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Jun. 15, 2015
The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);
Janssen Biotech, Inc., Spring House, PA (US);
Richard W. Childs, Rockville, MD (US);
Maria Berg, Bethesda, MD (US);
Luis Espinoza Calderon, Bethesda, MD (US);
Kate Sasser, Spring House, PA (US);
Ricardo Attar, Spring House, PA (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Janssen Biotech, Inc., Spring House, PA (US);
Abstract
Provided herein are methods of inhibiting growth or proliferation of cells expressing CD38 by contacting the CD38-expressing cells with 1) NK cells bound to an anti-CD38 F(ab')fragment and 2) an anti-CD38 antibody, in either order or simultaneously. Also provided herein are methods of treating or inhibiting a hyperproliferative disorder or an autoimmune disorder in a subject by administering to the subject 1) NK cells bound to an anti-CD38 F(ab′)fragment and 2) an anti-CD38 antibody, in either order or simultaneously.