The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Apr. 24, 2017
Viva Biotech (Shanghai) Ltd., Shanghai, CN;
Jianhua Cai, Shanghai, CN;
Jian Shen, Shanghai, CN;
Fan Jiang, Shanghai, CN;
Na Li, Shanghai, CN;
Wentao Wei, Shanghai, CN;
Xiuhong Zeng, Shanghai, CN;
Xiaoyan Su, Shanghai, CN;
Min Han, Shanghai, CN;
Delin Ren, Shanghai, CN;
Chen Mao, Shanghai, CN;
VIVA BIOTECH (SHANGHAI) LTD., Shanghai, CN;
Abstract
The present invention relates to fusion proteins for the expression of G-protein coupled receptor proteins (GPCR) with the fusion partners, as inserted fragments, from mammalian cells. The fusion partners are from a fragment of APJ protein ('the APJ protein fragment') or a fragment with homology of more than 90% similarity to the APJ protein fragment; or a fragment of RGS16 protein (the 'RGS16 protein fragment') or a fragment with homology of more than 90% similarity to the RGS16 protein fragment; or the fragment of DNJ protein (the “DNJ protein fragment”) or a fragment with homology of more than 90% similarity to DNJ protein fragment. The fusion expression of GPCR with the above mentioned fusion partners can improve the protein yield and stability when purified from cells. Therefore, these fusion protein partners can be widely used for the study of GPCR proteins.