The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Sep. 30, 2016
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Amy Chuong, Ashburn, VA (US);
Nathan Klapoetke, Ashburn, VA (US);
Brian Yichiun Chow, Cherry Hill, NJ (US);
Edward Boyden, Chestnut Hill, MA (US);
Xue Han, Chestnut Hill, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); C07K 14/215 (2006.01); C12N 5/071 (2010.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01); A61K 41/00 (2006.01); C12N 5/0793 (2010.01); C12N 5/16 (2006.01);
U.S. Cl.
CPC ...
C07K 14/215 (2013.01); A61K 38/164 (2013.01); A61K 41/0057 (2013.01); G01N 33/5032 (2013.01); C12N 5/0619 (2013.01); C12N 5/16 (2013.01); Y10S 530/825 (2013.01);
Abstract
Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modifiedhalorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.