The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Jun. 15, 2017
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Adrian Ortiz, Belle Meade, NJ (US);
Carlos A. Guerrero, Plainsboro, NJ (US);
Bin Zheng, Kendall Park, NJ (US);
Jason J. Zhu, East Brunswick, NJ (US);
Michael Anthony Schmidt, Woodbridge, NJ (US);
Michael R. Luzung, Jersey City, NJ (US);
Martin D. Eastgate, Titusville, NJ (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/12 (2006.01); C07F 7/18 (2006.01); C07D 211/28 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07F 7/1856 (2013.01); C07D 211/28 (2013.01); C07D 417/12 (2013.01); C07F 7/0818 (2013.01); C07F 7/1852 (2013.01);
Abstract
An improved process for making a compound B of the structure wherein n, R, R, and Rare as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.