The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
May. 04, 2016
Aza-phenalene-3-ketone derivative, preparation method thereof, and its application as parp inhibitor
Applicant:
Suzhou Kangrun Pharmaceuticals Inc., Wujiang, CN;
Inventors:
Yuping Chu, Wujiang, CN;
Weiliang Xu, Wujiang, CN;
Ling Wang, Wujiang, CN;
Weizheng Xu, Wujiang, CN;
Assignee:
SUZHOU KANGRUN PHARMACEUTICALS INC., Wujiang, CN;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/16 (2006.01);
U.S. Cl.
CPC ...
C07D 487/16 (2013.01);
Abstract
Disclosed are an aza-phenalene-3-ketone derivative, a preparation method thereof and its application as a PARP inhibitor. The aza-phenalene-3-ketone derivative has the following structure: wherein R is hydrogen, methyl, ethyl, isopropyl, benzyl or 3-methyl-3-butenyl. The aza-phenalene-3-ketone derivative has very high activity for inhibiting PARP, thereby providing a good basis for new drug research of developing a nitrogen-doped phenalene-3-ketone compound as PARP inhibitor to treat cancer.