The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Apr. 09, 2015
Siteone Therapeutics, Inc., Redwood City, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Hassan Pajouhesh, Redwood City, CA (US);
George Miljanich, Redwood City, CA (US);
John Mulcahy, Redwood City, CA (US);
Justin Du Bois, Menlo Park, CA (US);
Matthew Axtman, Cary, NC (US);
James Walker, Menlo Park, CA (US);
Jeffrey E. Merit, San Diego, CA (US);
SITEONE THERAPEUTICS, INC., Bozeman, MT (US);
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US);
Abstract
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10',11′-modified saxitoxins. The compounds are optionally additionally modified at carbon 13. In certain embodiments, the 10′,11′-modified saxitoxins are of Formula I: where R, Rand Rare as described herein. Also provided herein are methods of treating pain in a mammal comprising administering an effective treatment amount of a 10′,11′ modified saxitoxin or composition to a mammal. In an embodiment, the mammal is a human.