The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 23, 2018

Filed:

Feb. 20, 2018
Applicant:

Pharmacyclics Llc, Sunnyvale, CA (US);

Inventors:

Norbert Purro, Los Gatos, CA (US);

Mark S. Smyth, Foster City, CA (US);

Erick Goldman, Concord, CA (US);

David D. Wirth, Oak Ridge, NC (US);

Assignee:

Pharmacyclics LLC, Sunnyvale, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61J 1/03 (2006.01); A61K 9/00 (2006.01); B65D 75/36 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61J 1/035 (2013.01); A61K 9/0053 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/4825 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); B65D 75/36 (2013.01); C07B 2200/13 (2013.01);
Abstract

Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, solvates and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.


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