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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10106546 B1

PDFFull Text
Date of Patent:
Oct. 23, 2018

Filed:

Mar. 27, 2017

Immunoregulatory agents

Applicant:

Flexus Biosciences, Inc., Princeton, NJ (US);

Inventors:

Hilary Plake Beck, Emerald Hills, CA (US);

Juan Carlos Jaen, Burlingame, CA (US);

Maksim Osipov, Belmont, CA (US);

Jay Patrick Powers, Pacifica, CA (US);

Maureen Kay Reilly, Belmont, CA (US);

Hunter Paul Shunatona, San Francisco, CA (US);

James Ross Walker, Menlo Park, CA (US);

Mikhail Zibinsky, Lodi, CA (US);

James Aaron Balog, Lambertville, NJ (US);

David K. Williams, Delran, NJ (US);

Jay A. Markwalder, Lahaska, PA (US);

Emily Charlotte Cherney, Newtown, PA (US);

Weifang Shan, Princeton, NJ (US);

Audris Huang, New Hope, PA (US);

Assignee:

Flexus Biosciences, Inc., Princeton, NJ (US);

Attorney:

Baker & Hostetler LLP

Primary Examiner:

D Margaret M Seaman

Int. Cl.
CPC ...
A61K 31/47 (2006.01); C07D 487/04 (2006.01); C07D 215/06 (2006.01); C07D 231/56 (2006.01); A61K 31/416 (2006.01); C07D 215/233 (2006.01); C07D 471/04 (2006.01); A61K 31/437 (2006.01); C07D 239/74 (2006.01); A61K 31/517 (2006.01); A61K 31/4375 (2006.01); C07D 217/04 (2006.01); C07D 405/08 (2006.01); A61K 31/4709 (2006.01); C07D 417/08 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); A61K 31/506 (2006.01); A61K 31/496 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); C07D 215/14 (2006.01); C07D 405/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/416 (2013.01); A61K 31/437 (2013.01); A61K 31/4375 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); C07D 215/06 (2013.01); C07D 215/14 (2013.01); C07D 215/233 (2013.01); C07D 217/04 (2013.01); C07D 231/56 (2013.01); C07D 239/74 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/08 (2013.01); C07D 405/12 (2013.01); C07D 417/08 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01);
Abstract

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

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