The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Dec. 16, 2015
Janssen Pharmaceutica NV, Beerse, BE;
Andrés Avelino Trabanco-Suárez, Olias del Rey, ES;
Óscar Delgado-González, Madrid, ES;
Henricus Jacobus Maria Gijsen, Breda, NL;
Michiel Luc Maria Van Gool, Madrid, ES;
Sven Franciscus Anna Van Brandt, Beerse, BE;
Michel Anna Jozef De Cleyn, Lille, BE;
Santos Fustero Lardiés, Valencia, ES;
Natalia Mateu Sanchís, Cambridge, GB;
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase having the structure shown in Formula (I) wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with beta-amyloid, age-related macular degeneration, type 2 diabetes or metabolic disorders.