The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Jan. 12, 2016
Applicant:
Beijing Scitech-mq Pharmaceuticals Limited, Beijing, CN;
Inventors:
Assignee:
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED, Beijing, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/94 (2006.01); C07D 491/056 (2006.01); C07D 498/04 (2006.01); A61K 31/357 (2006.01); A61K 31/517 (2006.01); A61K 31/5375 (2006.01); A61K 39/395 (2006.01); C07D 405/14 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
C07D 239/94 (2013.01); A61K 31/357 (2013.01); A61K 31/517 (2013.01); A61K 31/5375 (2013.01); A61K 39/3955 (2013.01); A61P 35/02 (2018.01); C07D 405/14 (2013.01); C07D 491/056 (2013.01); C07D 498/04 (2013.01); A61K 2300/00 (2013.01);
Abstract
The present invention relates to an N-substituted-phenyl-5-substituted-alkoxy-2,3-dihydro-[1,4]dioxane[2,3-f]quinazolin-10-amine (I) or 4-substituted-arylamino-6-substituted-alkyl-6H-[1,4]oxazino[3,2-g]quinazoline-7(8H)-one (II) type compounds, a preparation method thereof and an application thereof as an inhibitor for epidermal growth factor receptor (EGFR) (comprising some mutant forms of EGFR) to treat cancer. These compounds and salts thereof can be used to treat or prevent various cancer diseases.