The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Mar. 25, 2016
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Brian M. Stoltz, San Marino, CA (US);
Alexander N. Marziale, Basel, CH;
Robert A. Craig, Stanford, CA (US);
Douglas Duquette, Los Angeles, CA (US);
Kelly E. Kim, Pasadena, CA (US);
Marc Liniger, Baden, CH;
Yoshitaka Numajiri, Kamakura, JP;
Assignee:
California Institute of Technology, Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/94 (2006.01); C07C 45/65 (2006.01); C07D 223/10 (2006.01); C07D 317/72 (2006.01); B01J 31/04 (2006.01);
U.S. Cl.
CPC ...
C07C 45/65 (2013.01); B01J 31/04 (2013.01); C07D 211/94 (2013.01); C07D 223/10 (2013.01); C07D 317/72 (2013.01); B01J 2231/44 (2013.01); B01J 2531/004 (2013.01); C07C 2601/14 (2017.05); C07C 2601/18 (2017.05); C07C 2601/20 (2017.05); C07C 2602/10 (2017.05);
Abstract
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.