The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Apr. 21, 2015
Applicant:
Fabrus, Inc., San Diego, CA (US);
Inventors:
Vaughn Smider, San Diego, CA (US);
Helen Hongyuan Mao, San Diego, CA (US);
Assignee:
Taurus Biosciences, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/04 (2006.01); G01N 33/68 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6845 (2013.01); C07K 16/00 (2013.01); C07K 16/28 (2013.01); C07K 16/2863 (2013.01); C07K 16/32 (2013.01); C12N 15/1058 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C40B 30/04 (2013.01);
Abstract
Provided herein is a rational method of affinity maturation to evolve the activity of an antibody or portion thereof based on the structure/affinity or activity relationship of an antibody. The resulting affinity matured antibodies exhibit improved or optimized binding affinity for a target antigen.