The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Aug. 22, 2016
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Bo Jiang, Norwich, VT (US);
Jun Zhuang, Wellesly, MA (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 16/00 (2006.01); C12N 15/81 (2006.01); C07K 14/39 (2006.01); C12N 15/80 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C12P 21/00 (2013.01); C07K 14/39 (2013.01); C07K 16/00 (2013.01); C12N 15/80 (2013.01); C12N 15/81 (2013.01); C12N 15/815 (2013.01); C12P 21/02 (2013.01); C07K 2317/14 (2013.01);
Abstract
The present invention provides CRZ1 mutant fungal host cells, such as. The mutant fungal host cells exhibit temperature-resistance, enhanced fermentation robustness and increased expression of heterologous polypeptides such as immunoglobulins. Methods for producing heterologous polypeptides, such as immunoglobulins, using such mutant fungal host cells are within the scope of the present invention.