The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Jul. 29, 2016
Applicant:
Monash University, Clayton, AU;
Inventors:
Siew Yeen Chai, Clayton, AU;
Robert Widdop, Clayton, AU;
Tracey Gaspari, Clayton, AU;
Huey Wen Lee, Clayton, AU;
Assignee:
MONASH UNIVERSITY, Clayton, Victoria, AU;
Primary Examiner:
Int. Cl.
CPC ...
A61P 1/16 (2006.01); A61K 31/395 (2006.01); A61K 31/351 (2006.01); A61P 13/12 (2006.01); A61P 9/00 (2006.01); A61K 31/4433 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/351 (2013.01); A61K 31/395 (2013.01); A61K 31/4433 (2013.01); A61P 1/16 (2018.01); A61P 9/00 (2018.01); A61P 13/12 (2018.01); C12N 2310/14 (2013.01);
Abstract
The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.