The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Oct. 02, 2014
Applicant:
Taiho Pharmaceutical Co., Ltd., Tokyo, JP;
Inventors:
Assignee:
Taiho Pharmaceutical Co., Ltd., Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 31/437 (2006.01); C12N 15/09 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); C07K 16/18 (2006.01); A61K 47/55 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61K 31/437 (2013.01); A61K 47/55 (2017.08); C07K 16/18 (2013.01); C12N 15/09 (2013.01); G01N 33/15 (2013.01); G01N 33/50 (2013.01); G01N 33/6872 (2013.01); G01N 33/6896 (2013.01); A61K 38/00 (2013.01); G01N 2333/47 (2013.01); G01N 2500/04 (2013.01); G01N 2800/52 (2013.01);
Abstract
An object to be solved by the present invention is to identify patients resistant to known HSP90 inhibitors, and to provide a novel therapeutic agent for treating the patients who have become resistant to known HSP90 inhibitors. As a means for solving the above problems, the present invention provides identification of the patients based on a protein, which is an HSP90 family protein having a mutation in the site corresponding to F138 of HSP90α class A consisting of the amino acid sequence of SEQ ID NO: 1, and use of a substance that inhibits the protein as an active ingredient of a therapeutic agent.