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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10100076 B1

PDFFull Text
Date of Patent:
Oct. 16, 2018

Filed:

Jun. 03, 2013

Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation

Applicant:

Gilead Pharmasset Llc, Foster City, CA (US);

Inventors:

Lieven Stuyver, Snellville, GA (US);

Kyoichi Watanabe, Stone Mountain, GA (US);

Assignee:

Gilead Pharmasset LLC, Foster City, CA (US);

Attorney:
Primary Examiner:

Traviss C McIntosh, III

Int. Cl.
CPC ...
A61K 31/7076 (2006.01); A61K 31/7064 (2006.01); C07H 19/16 (2006.01); C07H 19/048 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07H 19/20 (2006.01); C07H 21/04 (2006.01); C12Q 1/6809 (2018.01); C12Q 1/689 (2018.01); C12Q 1/6895 (2018.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01); A61K 31/7064 (2013.01); A61K 31/7076 (2013.01); C07H 19/048 (2013.01); C07H 19/06 (2013.01); C07H 19/10 (2013.01); C07H 19/20 (2013.01); C07H 21/04 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/689 (2013.01); C12Q 1/6895 (2013.01); Y02A 50/393 (2018.01);
Abstract

The disclosed invention is a composition for and a method of seating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction ('RT-PCR'). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.

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