The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 16, 2018

Filed:

Nov. 29, 2017
Applicant:

Gilead Sciences, Inc., Foster City, CA (US);

Inventors:

Elfatih Elzein, Mountain House, CA (US);

Rao V. Kalla, Cupertino, CA (US);

Dmitry Koltun, Foster City, CA (US);

Xiaofen Li, Mountain View, CA (US);

Eric Q. Parkhill, San Francisco, CA (US);

Thao Perry, San Jose, CA (US);

Scott Preston Simonovich, Oakland, CA (US);

Jeff Zablocki, Los Altos, CA (US);

Christopher Allen Ziebenhaus, San Francisco, CA (US);

Assignee:

Gilead Sciences, Inc., Foster City, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial fibrillation and myocardial infarction. In particular embodiments, the general structure of the compounds is given by Formula I: wherein R, R, R, R, R, R, Rand Rare as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.


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