The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Dec. 14, 2015
Shenyang Sunshine Pharmaceutical Co. Ltd., Shenyang, Liaoning, CN;
Yunlong Zhou, Nanjing, CN;
Suixiong Cai, San Diego, CA (US);
Guangfeng Wang, Shanghai, CN;
Lingling Jiao, Taizhou, CN;
Ping Min, Shanghai, CN;
Yu Jing, Taizhou, CN;
Ming Guo, San Diego, CA (US);
SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD., Shenyang, Liaoning, CN;
Abstract
A compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof are provided. In particular, the compound has the following Formula (I), wherein Rand Rare each independently H; Ris H or C-Calkyl; Ar is an aromatic ring or a heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring. Pharmaceutically acceptable salts of the present compound, are provided, as well as uses of the compound or pharmaceutically acceptable salts thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO.