The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Mar. 23, 2017
Medical Research Council, Swindon, GB;
Inflectis Bioscience, Nantes, FR;
Philippe Guedat, Montenois, FR;
Anne Bertolotti, Cambridge, GB;
United Kingdom Research and Innovation, Sindon, GB;
InFlectis BioScience, Nantes, FR;
Abstract
The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof, wherein: Ris alkyl, Cl, F or Br; Ris H or F; Ris selected from H and alkyl; Ris selected from H and C(O)R; Ris H; or Rand Rare linked to form a heterocyclic group which is optionally substituted with one or more Rgroups; Ris selected from R, ORand NRR; R, Rand Rare each independently selected from alkyl, cycloalkyl, aralkyl, cycloalkenyl, heterocyclyl and aryl, each of which is optionally substituted with one or more Rgroups; each Ris independently selected from halogen, OH, CN, NO, COO-alkyl, aralkyl, SO-alkyl, SO-aryl, COOH, CO-alkyl, CO-aryl, NH, NH-alkyl, N(alkyl), CF, alkyl and alkoxy; X and Z are each independently CR, and Y is selected from CRand N; and Ris H or F; for use in treating a disorder associated with protein misfolding stress and in particular associated with accumulation of misfolded proteins.