The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 16, 2018

Filed:

Dec. 17, 2015
Applicant:

Pharmaseq, Inc., Monmouth Junction, NJ (US);

Inventors:

Wlodek Mandecki, Princeton Junction, NJ (US);

Efrain “Frank” Rodriguez, Bordentown, NJ (US);

Ziye “Jay” Qian, Monroe Township, NJ (US);

Assignee:

PharmaSeq, Inc., Monmouth Junction, unknown;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 20/04 (2006.01); B01J 19/00 (2006.01); C40B 50/16 (2006.01); C40B 60/14 (2006.01); C40B 70/00 (2006.01);
U.S. Cl.
CPC ...
B01J 19/0046 (2013.01); C40B 20/04 (2013.01); C40B 50/16 (2013.01); C40B 60/14 (2013.01); C40B 70/00 (2013.01); B01J 2219/00306 (2013.01); B01J 2219/00531 (2013.01); B01J 2219/00567 (2013.01); B01J 2219/00587 (2013.01); B01J 2219/00596 (2013.01); B01J 2219/00675 (2013.01); B01J 2219/00689 (2013.01); B01J 2219/00704 (2013.01); B01J 2219/00722 (2013.01); B01J 2219/00725 (2013.01);
Abstract

Provided is a method of synthesis comprising: (I) providing separate reaction sequences to TABs; (II) utilizing reaction vessels configured to react a separate combinatorial building block with a moiety on a surface of a TAB; and (III) operating one or more TAB sorters comprising a TAB reader, a sorting tree comprising valves or switches and sorting nodes, and a monitor configured to detect TAB location, wherein the operating comprises serially conducting: (a) reacting distinct combinatorial building blocks in the reaction chambers with surfaces of TABs distributed in the reaction chambers; (b) operating a controller to operate the TAB sorters to segregate the TABs to allocations appropriate for the next assigned reaction, the operating including recycling TABs with ambiguous identity back through the sorter; and (c) repeating steps (a) and (b) as needed to complete 30% or more of the assigned sequences.


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