The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Oct. 23, 2017
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Jonathan Schneck, Silver Spring, MD (US);
Karlo Perica, Baltimore, MD (US);
Joan Glick Bieler, Silver Spring, MD (US);
Mathias Oelke, Parkville, MD (US);
Assignee:
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); B03C 1/01 (2006.01); C12N 5/06 (2006.01); B03C 1/28 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); C12N 5/0783 (2010.01); C12N 13/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0011 (2013.01); B03C 1/01 (2013.01); B03C 1/288 (2013.01); C12N 5/0637 (2013.01); C12N 5/0638 (2013.01); C12N 13/00 (2013.01); G01N 33/505 (2013.01); G01N 33/5011 (2013.01); G01N 33/56972 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/572 (2013.01); B03C 2201/18 (2013.01); B03C 2201/20 (2013.01); G01N 2333/70539 (2013.01);
Abstract
Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.