The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Jul. 04, 2016
Applicants:
Leslie B. Gordon, Foxboro, MA (US);
Mark W. Kieran, Newton, MA (US);
Monica E. Kleinman, Sharon, MA (US);
Inventors:
Leslie B. Gordon, Foxboro, MA (US);
Mark W. Kieran, Newton, MA (US);
Monica E. Kleinman, Sharon, MA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/21 (2006.01); A61K 31/44 (2006.01); A61K 31/675 (2006.01); A61K 31/436 (2006.01); A61K 31/4545 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 45/06 (2006.01); A61K 31/22 (2006.01); A61K 31/55 (2006.01); A61K 31/663 (2006.01);
U.S. Cl.
CPC ...
A61K 31/436 (2013.01); A61K 9/0053 (2013.01); A61K 9/20 (2013.01); A61K 31/22 (2013.01); A61K 31/4545 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); A61K 31/55 (2013.01); A61K 31/663 (2013.01);
Abstract
Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.