The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 16, 2018

Filed:

Oct. 05, 2015
Applicant:

Nanoform Finland Oy, Helsinki, FI;

Inventors:

Edward Haeggström, Helsinki, FI;

Jouko Yliruusi, Vantaa, FI;

Kai Falck, Helsinki, FI;

Heikki Räikkönen, Helsinki, FI;

Jenni Pessi, Helsinki, FI;

Ilkka Lassila, Helsinki, FI;

Antti Meriläinen, Helsinki, FI;

Assignee:

Nanoform Finland Oy, Helsinki, FI;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01J 3/00 (2006.01); A61K 9/14 (2006.01); A61K 31/5415 (2006.01);
U.S. Cl.
CPC ...
A61K 9/14 (2013.01); A61K 31/5415 (2013.01); B01J 3/008 (2013.01); Y02P 20/544 (2015.11);
Abstract

The invention relates to a method and a device for producing nanoparticles of organic substances, in particular by controlled expansion of pressurized solutions. The method comprises: admixing the organic substance and a supercritical fluid to form a mixture at a first pressure; decreasing the first pressure gradually to a second pressure so that a flow of the mixture is formed and nucleation of the organic substance in the mixture is initiated; and, decreasing the second pressure to a third pressure, so that solidification of the fluid of the mixture, comprising the nucleated organic substance, is initiated. The device comprises: a pressure chamber () for a mixture of the organic substance and a supercritical fluid; a collection chamber () for the nanoparticles; an outlet tube () connecting the pressure chamber to the collection chamber (); and, one or more second nozzles (). The outlet tube is provided with a pressure controlling means () configured to control pressure of the mixture within the outlet tube and a first nozzle () configured to allow expansion of the mixture to the collection chamber.


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