The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 09, 2018

Filed:

May. 26, 2017
Applicant:

Whitehead Institute for Biomedical Research, Cambridge, MA (US);

Inventors:

Rudolf Jaenisch, Brookline, MA (US);

Yaqub Hanna, Boston, MA (US);

Marius Wernig, Woodside, CA (US);

Christopher J. Lengner, Wellesley, MA (US);

Alexander Meissner, Cambridge, MA (US);

Oliver Tobias Brambrink, Cambridge, MA (US);

G. Grant Welstead, Cambridge, MA (US);

Ruth Foreman, Somerville, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/074 (2010.01); C07K 14/47 (2006.01); A01K 67/027 (2006.01); G01N 33/50 (2006.01); C12N 15/877 (2010.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C07K 14/4702 (2013.01); A01K 67/0273 (2013.01); A01K 67/0275 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); C12N 15/8509 (2013.01); C12N 15/8775 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/605 (2013.01); C12N 2501/606 (2013.01); C12N 2506/11 (2013.01); C12N 2506/13 (2013.01); C12N 2800/30 (2013.01); C12N 2830/003 (2013.01); C12N 2830/006 (2013.01); G01N 33/5023 (2013.01); G01N 2333/91011 (2013.01);
Abstract

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.


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