The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
May. 09, 2014
Applicant:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (US);
Inventors:
David W. Scott, Bethesda, MD (US);
Yong Chan Kim, Rockville, MD (US);
Assignee:
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC., Bethesda, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A01N 63/00 (2006.01); C12N 5/0783 (2010.01); A61K 39/00 (2006.01); A61K 35/17 (2015.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0637 (2013.01); A61K 35/17 (2013.01); A61K 39/0008 (2013.01); C07K 14/7051 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/57 (2013.01); A61K 2039/572 (2013.01); C12N 2502/11 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention generally relates to the production of antigen-specific T regulatory cells (Tregs). Such cells can be used in therapy to minimize undesirable immune responses such as those observed in autoimmunity and hemophilia and other diseases as well as in the response to protein therapy for genetic diseases. Methods for producing antigen specific Tregs and conditions for preferential expansion of functionally stable, specific Tregs are also provided.